Prevage™ MD Maximum-strength topical antioxidant

What is PREVAGE™ MD?
PREVAGE™ MD is an anti-aging treatment with the key ingredient idebenone, the most powerful antioxidant available in a skin care product today. The 1% strength of idebenone is available only in PREVAGE™ MD and only from your doctor.

Applying PREVAGE™ MD anti-aging treatment to your face and neck once or twice a day:
- Reduces the appearance of fine lines and wrinkles
- Improves the overall apperance of your skin
- Protects your skin from environmental stressors known to cause skin aging

Why use an antioxidant on your skin?
You may have heard about the negative effects of free radicals inside the body and the value of adding antioxidants to your diet to counter the effects of free radicals. Free radicals accumulate in your skin, not only from the effects of environmental stressors (UV light, air pollution, ozone, and cigarette smoke), but also from the aging process itself.
The effects of stressors on your skin cannot be combated with simple cleansing. To remove free radicals, you need a topical antioxidant like PREVAGE™ MD anti-aging treatment, which protects against skin damage by chemically trapping and neutralizing each free radical it touches. Think of antioxidants as guardians of your skin cells, protecting them from free radicals and allowing the production of healthier cells.

Does PREVAGE™ MD anti-aging treatment work better than other topical antioxidants?
Yes. The 1% concentration of idebenone found in PREVAGE™ MD anti-aging treatment is scientifically shown to be more effective than other topical antioxidants in protecting your skin against environmental stressors known to cause skin aging.1 These other antioxidants include kinetin (used in Kinerase®), coenzyme Q10 (Q10 Plus Wrinkle Control products from Nivea®), lipoic acid (used in N.V. Perricone M.D. Cosmeceuticals®), vitamin C, and vitamin E (found in many anti-aging products).

What can idebenone 1% do for my skin?
Idebenone 1% anti-aging treatment helps correct the skin damage that you already have and also protects your skin from future damage. The antioxidative power of PREVAGE™ MD has been clinically shown to reduce the signs of skin aging in only 4 weeks.2
In a recent survey:
– 72% of subjects reported reduction in the appearance of fine lines and wrinkles
– 78% of subjects reported reduction in roughness and dryness
– 78% of subjects reported improvement in skin softness and smoothness
– 61% of subjects reported improvement in firmness, tightness, and elasticity
– 67% of subjects reported improvement in overall appearance
In addition, a majority of subjects reported an overall improvement in their skin’s health after just 4 weeks of use.

How do I use PREVAGE™ MD anti-aging treatment?
Before using PREVAGE™ MD regularly, it is recommended you test by applying a small amount (less than one pump) daily for several days to a small area on the forearm near the inner side of the elbow or to a very small area of the neck or face that will receive regular treatment. Skin reactions to PREVAGE™ MD, though rare, are likely to occur within the first few days of use. If any reaction occurs, wash the product off and discontinue use.

Regular usage of PREVAGE™ MD anti-aging treatment.
PREVAGE™ MD is always applied to clean, dry skin. If you use a moisturizer, apply it after PREVAGE™ MD.
If you have normal skin sensitivity, begin using PREVAGE™ MD once a day for the first week and, if you have no skin reactions, twice a day from then on.
Even though PREVAGE™ MD anti-aging treatment protects your skin against environmental stressors, it is not a substitute for sunscreen. Always use a sunscreen with a minimum of SPF 15 every day.

How much PREVAGE™ MD should I use?
Push the pump down once or twice to dispense a pea-size amount. Thoroughly massage PREVAGE™ MD anti-aging treatment into your clean, dry face and neck once a day or as instructed by your doctor.

Can I use PREVAGE™ MD in combination with other products?
PREVAGE™ MD anti-aging treatment can be used with most other products including moisturizers, sunscreens, and cosmetics. Apply PREVAGE™ MD directly after cleansing; you can then apply your other products normally.
In general, apply PREVAGE™ MD directly after cleansing your skin and before applying any other products.

Will PREVAGE™ MD cause burning or stinging?
No. In patient trials PREVAGE™ MD anti-aging treatment did not cause burning or stinging.

Will PREVAGE™ MD cause any other skin reactions?
Whether or not they have sensitive skin, some people experience breakouts any time their skin care regimen changes. If this happens, it is recommended that, to reduce the possibility of a breakout, you should use PREVAGE™ MD anti-aging treatment every other day for the first week and then begin using it once a day.

You can find more information about PREVAGE™ MD anti-aging treatment on their web site.

1. McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA II, Maibach HI. Idebenone: a new antioxidant—part I. A relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosm Derm. 2005;4(1):10-17. 2. Data on file, Allergan, Inc.
Kinerase is a registered trademark of Valeant Pharmaceuticals International. Nivea is a registered trademark of Beiersdorf AG. N.V. Perricone M.D. Cosmeceuticals is a registered trademark of N.V. Perricone M.D., Limited.